Go to a major interstate motor park in Zaria. Reliable parks include Zaria Central Motor Park or you may need to travel to Kawo or Mando Motor Park in Kaduna city if direct Zaria-Onitsha buses are limited. Purchase your ticket from a reputable company like GIGM, GUO Transport, or Peace Mass Transit.

Board your assigned Luxury or Coaster bus. Ensure your luggage is properly loaded and tagged. Buses usually depart once full or at scheduled times. The journey begins on the A2, heading south.

Travel through Kaduna State, connecting to the Abuja-Kaduna Highway. You will pass through Abuja (Nnamdi Azikwe Way) and continue south towards Lokoja. There will be rest stops, typically in Lokoja, for passengers to stretch, use restrooms, and buy food/drinks.

Continue the journey, passing through Okene, Benin City (using the A2 and F116), and then towards Asaba/Onitsha (A232, Onitsha-Asaba Road). Be prepared for various police and military checkpoints along the route. Road conditions can vary, from good dual carriageways to sections with potholes.

Arrive at the major interstate terminal in Onitsha, most commonly at Upper Iweka. From here, you can connect to your final destination within Onitsha using local transport like Keke Napep (tricycle) or commercial motorcycles ('okada').